Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | GLA | P06280 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.57 |
| ▸ | CA9 | Q16790 | 3/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CA3 | P07451 | 2/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.57 |
| ▸ | CA6 | P23280 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033540 | 0.88 | KDM4E (0.58) | ALDH1A1HPGDMAOBGAACA12 | |
| SCHEMBL13620670 | 0.82 | KDM4E (0.62) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL29002816 | 0.81 | CA12 (0.62) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL13486864 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL28533299 | 0.80 | MAOB (0.57) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL13486865 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL15842248 | 0.79 | ALDH1A1 (0.63) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL566297 | 0.79 | APP (0.58) | ALDH1A1HPGDMAOBGAAGLA | |
| SCHEMBL5288407 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HPGDMAOBGAAMEN1 | |
| SCHEMBL10305766 | 0.79 | ALDH1A1 (0.63) | ALDH1A1HPGDMAOBGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114877-A1 | FLUORESCENT PARTICULATE MATERIAL | L'OREAL (FR) | 2017-07-06 | — | — | WO | disclosed |
| US-20100048604-A1 | Ligands for Aldoketoreductases | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2010-02-25 | — | — | US | disclosed |
| US-6545031-B1 | Carboxyalkenylpyrazolylbenzene derivatives, such as (E)-alpha-((5-(2-((2-carboxyphenyl)methoxy)-4-methoxyphenyl) -1-ethyl-1H-pyrazol-4-yl)methylene)-6-methoxy-1,3-benzodioxole -5-propanoic acid | SMITHKLINE BEECHAM CORPORATION | 2003-04-08 | — | — | US | disclosed |
| EP-0841926-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0843551-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6174906-B1 | TREATMENT OF DISEASES CAUSED BY AN EXCESS OF ENDOTHELIN COMPRISING ADMINISTERING ENDOTHELIN RECEPTOR ANTAGONIST COMPOUND; FOR TREATING UNSTABLE ANGINA, CORONARY VASOSPASM AND MYOCARDIAL SALVAGE, RESTENOSIS, PULMONARY HYPERTENSION | SMITHKLINE BEECHAM CORPORATION | 2001-01-16 | — | — | US | disclosed |
| US-6030970-A | TREATING RENAL FAILURE OR CEREBROVASCULAR DISEASE, RADIO-CONTRAST INDUCED RENAL FAILURE, CONGESTIVE HEART FAILURE, UNSTABLE ANGINA, CORONARY VASOPASM, MYOCARDIAL SALVAGE, RESTENOSIS, PULMONARY HYPERTENSION, STROKES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-29 | — | — | US | disclosed |
| EP-0841926-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0843551-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1998-08-12 | — | — | EP | disclosed |
| EP-0843551-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-27 | — | — | EP | disclosed |
| EP-0841926-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004774-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-13 | — | — | WO | disclosed |
| WO-1997004773-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-13 | — | — | WO | disclosed |
| US-4098799-A | ANTIALLERGENS, HYPERACIDITY | WARNER-LAMBERT COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
| US-4008252-A | ANTIALLERGENS, ANTIHYPERACIDITY | WARNER-LAMBERT COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048604-A1 | Ligands for Aldoketoreductases | AKR1C2, AKR1C1, AKR1B1 | ALDH1A1 18/4885HPGD 59/4885MAOB 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.