Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.93 |
| ▸ | HPGD | P15428 | 3/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.83 |
| ▸ | PKM | P14618 | 1/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9492603 | 0.88 | ALDH1A1 (0.76) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL10971124 | 0.84 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL13602366 | 0.84 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL10160183 | 0.83 | SMN1; SMN2 (0.85) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL5149346 | 0.83 | ALDH1A1 (0.69) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL18798610 | 0.83 | ALDH1A1 (0.69) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL6962322 | 0.83 | MEN1 (0.70) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL1083633 | 0.83 | MEN1 (0.77) | ALDH1A1HPGDSMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL27723289 | 0.82 | ALDH1A1 (0.83) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 | |
| SCHEMBL15923520 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDSMN1; SMN2PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| CN-1071746-C | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 2001-09-26 | — | — | CN | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| CN-1132505-A | Amidine derivatives with nitric oxide synthetase activities | ASTERA CO (SE) | 1996-10-02 | — | — | CN | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |