Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.85 |
| ▸ | HPGD | P15428 | 4/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.85 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.73 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.73 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156900 | 0.86 | ALDH1A1 (0.67) | SMN1; SMN2HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL2828273 | 0.86 | ALDH1A1 (0.67) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| SCHEMBL2828269 | 0.86 | ALDH1A1 (0.67) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| SCHEMBL6962971 | 0.85 | SMN1; SMN2 (0.89) | SMN1; SMN2HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL11024162 | 0.85 | RAB9A (1.00) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| SCHEMBL4067332 | 0.83 | PKM (0.82) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| Dinitrophenylene SCHEMBL27269874 | 0.83 | ALDH1A1 (0.67) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| SCHEMBL6967304 | 0.83 | ALDH1A1 (0.93) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| SCHEMBL27723289 | 0.83 | ALDH1A1 (0.83) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A | |
| Nitric Acid SCHEMBL18329349 | 0.83 | RAB9A (0.76) | SMN1; SMN2HPGDALDH1A1L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093266-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20100041645-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
| CN-1989138-A | 2-Substituted-4-heteroaryl-pyrimidines useful in the treatment of proliferative diseases | CYCLACEL LTD (GB) | 2007-06-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | CIT, ROCK1, RHOT2 | SMN1; SMN2 2901/4885HPGD 419/4885ALDH1A1 3661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.