Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960498 | 0.88 | HDAC1 (0.45) | ALDH1A1MAPTPTPN1GAAMTNR1A | |
| SCHEMBL8888759 | 0.86 | PTPN1 (0.42) | ALDH1A1KDM4EHPGDMAPTPTPN1 | |
| SCHEMBL6973327 | 0.86 | PTPN1 (0.42) | ALDH1A1KDM4EHPGDMAPTPTPN1 | |
| SCHEMBL6969220 | 0.85 | PTPN1 (0.44) | ALDH1A1PTPN1SMN1; SMN2GAAMTNR1A | |
| SCHEMBL6584211 | 0.84 | PPARG (0.57) | ALDH1A1KDM4EHPGDMAPTTP53 | |
| SCHEMBL6973328 | 0.84 | PTPN1 (0.45) | ALDH1A1MAPTPTPN1GAAMTNR1A | |
| SCHEMBL6967428 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMAPTTP53 | |
| SCHEMBL6584217 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EHPGDMAPTTP53 | |
| SCHEMBL6973190 | 0.81 | PTPN1 (0.43) | ALDH1A1KDM4EMAPTPTPN1GAA | |
| SCHEMBL4727180 | 0.81 | PPARG (0.57) | MAPTPTPN1SMN1; SMN2KCNH2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |