Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.46 |
| ▸ | ITGAV | P06756 | 2/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249845 | 0.81 | TSHR (0.67) | SMN1; SMN2POLBHTTALDH1A1ITGB3 | |
| SCHEMBL6956276 | 0.80 | CNR2 (0.65) | SMN1; SMN2HTTALDH1A1NCOA1NCOA3 | |
| SCHEMBL28760324 | 0.80 | CNR2 (0.65) | SMN1; SMN2HTTALDH1A1NCOA1NCOA3 | |
| SCHEMBL27558113 | 0.80 | CNR2 (0.65) | SMN1; SMN2HTTALDH1A1NCOA1NCOA3 | |
| SCHEMBL6156731 | 0.79 | CASP1 (0.60) | ALDH1A1CASP1 | |
| SCHEMBL6955527 | 0.79 | CASP1 (0.60) | ALDH1A1CASP1 | |
| SCHEMBL6156740 | 0.79 | CASP1 (0.60) | ALDH1A1CASP1 | |
| SCHEMBL6957157 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL6963806 | 0.79 | ATM (0.51) | SMN1; SMN2HTTPTPRCPTPN1TSHR | |
| SCHEMBL7146807 | 0.79 | CYP3A4 (0.54) | SMN1; SMN2HTTALDH1A1CASP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| US-5830869-A | METALLOPROTEASE INHIBITOR | PHARMACIA & UPJOHN COMPANY | 1998-11-03 | — | — | US | disclosed |