Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6372054 | 0.84 | POLB (0.39) | POLBSPHK1SMN1; SMN2LMNACTSK | |
| SCHEMBL28214652 | 0.84 | POLB (0.39) | POLBSPHK1SMN1; SMN2LMNASCN3A | |
| SCHEMBL23279350 | 0.81 | SMN1; SMN2 (0.44) | POLBSPHK1SMN1; SMN2LMNAKCNK3 | |
| SCHEMBL6808603 | 0.81 | SMN1; SMN2 (0.44) | POLBSPHK1SMN1; SMN2LMNAKCNK3 | |
| SCHEMBL25574880 | 0.79 | LMNA (0.37) | LMNAKDM4E | |
| SCHEMBL3969870 | 0.79 | LMNA (0.52) | POLBSPHK1SMN1; SMN2LMNAKCNK3 | |
| SCHEMBL20143218 | 0.79 | LMNA (0.52) | POLBSPHK1SMN1; SMN2LMNAKCNK3 | |
| SCHEMBL2177821 | 0.78 | LMNA (0.46) | SMN1; SMN2LMNAKDM4E | |
| SCHEMBL27146149 | 0.78 | POLB (0.43) | POLBSPHK1LMNASCN3AMAOA | |
| SCHEMBL27146148 | 0.78 | POLB (0.43) | POLBSPHK1LMNASCN3AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |