Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970202 | 0.93 | KCNH2 (0.45) | KCNH2ABCG2MEN1KMT2AMAPT | |
| SCHEMBL6977278 | 0.90 | KCNH2 (0.45) | KCNH2ABCG2MEN1KMT2AMAPT | |
| SCHEMBL6980438 | 0.88 | MAPT (0.38) | KCNH2MEN1KMT2AMAPTMCHR1 | |
| SCHEMBL10639001 | 0.88 | PSEN1 (0.40) | ABCG2MEN1KMT2AMAPTTDP1 | |
| SCHEMBL6969675 | 0.88 | MEN1 (0.38) | KCNH2MEN1KMT2AMAPTMCHR1 | |
| SCHEMBL6978127 | 0.85 | TTPA (0.47) | KCNH2MEN1KMT2AMAPT | |
| SCHEMBL8486214 | 0.84 | PSEN1 (0.39) | MEN1KMT2AMAPTTDP1PSEN1 | |
| SCHEMBL6967865 | 0.82 | HPGD (0.51) | MEN1KMT2A | |
| SCHEMBL6967873 | 0.82 | HPGD (0.51) | MEN1KMT2A | |
| SCHEMBL6975450 | 0.82 | PPARG (0.41) | MEN1KMT2AMAPTTDP1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |