Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969241 | 0.80 | MAPT (0.72) | MAPTHTR1AHPGDPOLBMEN1 | |
| SCHEMBL6970489 | 0.70 | MAPT (0.64) | MAPTHTR1AHPGDPOLBMEN1 | |
| SCHEMBL9701396 | 0.63 | CASR (0.56) | HTR1AHPGDCASRPOLBMTNR1A | |
| SCHEMBL9077031 | 0.63 | KMT2A (0.52) | MAPTHTR1APOLBMEN1KMT2A | |
| SCHEMBL1759590 | 0.62 | NR4A2 (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL3918274 | 0.62 | NR4A2 (0.56) | MAPTMEN1KMT2A | |
| SCHEMBL27909433 | 0.62 | NR4A2 (0.46) | MAPTPOLBMEN1KMT2ARECQL | |
| SCHEMBL8562534 | 0.61 | HPGD (0.65) | HPGDPOLBKMT2AMTNR1AMTNR1B | |
| SCHEMBL8562529 | 0.61 | HPGD (0.65) | HPGDPOLBKMT2AMTNR1AMTNR1B | |
| SCHEMBL8564576 | 0.61 | HPGD (0.65) | HPGDPOLBKMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6313114-B1 | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |
| EP-1140925-A1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040580-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINYL-METHYL[3-(1H-INDOL-3-YL)-ALKYL]-AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |