Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | NMUR2 | Q9GZQ4 | 2/20 | 0.34 |
| ▸ | NMUR1 | Q9HB89 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2526255 | 0.88 | F2 (0.46) | F2PRSS1 | |
| SCHEMBL7504596 | 0.86 | F2 (0.45) | F2PRSS1 | |
| SCHEMBL7506385 | 0.86 | F2 (0.40) | F2PRSS1NMUR2NMUR1EPHA2 | |
| SCHEMBL8939612 | 0.86 | F2 (0.40) | F2NMUR2NMUR1EPHA2 | |
| SCHEMBL7502292 | 0.86 | F2 (0.36) | F2OPRM1OPRK1NMUR2NMUR1 | |
| SCHEMBL8939651 | 0.85 | EPHA2 (0.35) | F2OPRM1OPRK1NMUR2NMUR1 | |
| SCHEMBL6976859 | 0.85 | F2 (0.39) | F2PRSS1 | |
| SCHEMBL8939663 | 0.85 | F2 (0.39) | F2PRSS1 | |
| SCHEMBL7496053 | 0.84 | TP53 (0.39) | F2OPRM1OPRK1 | |
| SCHEMBL7546883 | 0.83 | F2 (0.41) | F2PRSS1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833839-B1 | PEPTIDYL HETEROCYCLES USEFUL IN THE TREATMENT OF THROMBIN RELATED DISORDERS | ORTHO PHARMA CORP (US) | 2003-01-08 | — | — | EP | claimed |
| WO-1996040748-A1 | PEPTIDYL HETEROCYCLES USEFUL IN THE TREATMENT OF THROMBIN RELATED DISORDERS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| US-5523308-A | SERINE PROTEASES INHIBITORS; ORAL ANTICOAGULANTS; CHEMICAL INTERMEDIATES; DIPEPTIDES | ORTHO PHARMACEUTICAL CORPORATION | 1996-06-04 | — | — | US | claimed |
| US-5523308-A | SERINE PROTEASES INHIBITORS; ORAL ANTICOAGULANTS; CHEMICAL INTERMEDIATES; DIPEPTIDES | ORTHO PHARMACEUTICAL CORPORATION | 1996-06-04 | — | — | US | disclosed |