Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713032 | 0.82 | CYP3A4 (0.51) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL12781853 | 0.79 | CYP3A4 (0.54) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL3670353 | 0.77 | ALDH1A1 (0.47) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL6582676 | 0.76 | CYP3A4 (0.46) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL31405856 | 0.76 | CYP3A4 (0.46) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL31405855 | 0.75 | ALDH1A1 (0.48) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL10607668 | 0.73 | CYP3A4 (0.46) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL3952609 | 0.73 | TUBB4A (0.47) | CYP3A4ACHE | |
| SCHEMBL6583176 | 0.72 | CYP3A4 (0.45) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB | |
| SCHEMBL8144226 | 0.72 | CYP3A4 (0.57) | CYP3A4ALDH1A1SMN1; SMN2ACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149092-B1 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| CN-1331689-A | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles | HOFFMANN LA ROCHE (CH) | 2002-01-16 | — | — | CN | disclosed |
| US-6313310-B1 | JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |
| EP-1149092-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000035906-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |