Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15033052 | 0.87 | SIGMAR1 (0.60) | NPY5RSIGMAR1DRD4CHRM2CHRM1 | |
| SCHEMBL178929 | 0.87 | KMT2A (0.63) | SIGMAR1DRD4KMT2AL3MBTL1KCNA3 | |
| SCHEMBL2241423 | 0.87 | KMT2A (0.63) | SIGMAR1DRD4KMT2AL3MBTL1KCNA3 | |
| SCHEMBL2241424 | 0.87 | KMT2A (0.63) | SIGMAR1DRD4KMT2AL3MBTL1KCNA3 | |
| SCHEMBL16200816 | 0.85 | SIGMAR1 (0.52) | NPY5RSIGMAR1DRD4CHRM2CHRM1 | |
| SCHEMBL16200832 | 0.84 | SIGMAR1 (0.52) | NPY5RSIGMAR1DRD4CHRM2CHRM1 | |
| SCHEMBL7656471 | 0.83 | SIGMAR1 (0.65) | SIGMAR1DRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL10135613 | 0.83 | MCHR1 (0.51) | NPY5RMCHR1 | |
| SCHEMBL10135593 | 0.83 | MCHR1 (0.51) | NPY5RMCHR1 | |
| SCHEMBL1412221 | 0.83 | KMT2A (0.58) | SIGMAR1DRD4KDM4EKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562964-B1 | Inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders | PFIZER INC | 2003-05-13 | — | — | US | disclosed |
| EP-1100797-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-6372736-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-04-16 | — | — | US | disclosed |