Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6979143 | 0.99 | CCR3 (0.44) | CCR3SIGMAR1OPRL1DRD4DRD2 | |
| SCHEMBL11743900 | 0.82 | SIGMAR1 (0.66) | CCR3SIGMAR1OPRL1DRD4POLB | |
| SCHEMBL6964254 | 0.79 | HRH4 (0.57) | CCR3SIGMAR1 | |
| SCHEMBL6976116 | 0.77 | CCR3 (0.46) | CCR3SIGMAR1OPRL1DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL6971416 | 0.76 | CCR3 (0.45) | CCR3SIGMAR1OPRL1DRD4DRD2 | |
| SCHEMBL6969667 | 0.76 | CCR3 (0.43) | CCR3SIGMAR1OPRL1DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL6978470 | 0.75 | CCR3 (0.42) | CCR3SIGMAR1OPRL1DRD4DRD2 | |
| SCHEMBL6952807 | 0.74 | SIGMAR1 (0.45) | SIGMAR1POLBMEN1KMT2AMAPT | |
| SCHEMBL11738755 | 0.73 | OPRL1 (0.69) | CCR3SIGMAR1OPRL1DRD4DRD2 | |
| SCHEMBL9023871 | 0.72 | SIGMAR1 (0.44) | SIGMAR1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |