Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952807 | 0.86 | SIGMAR1 (0.45) | SIGMAR1HPGDSCYP3A4CYP2D6CYP2A6 | |
| SCHEMBL20457833 | 0.86 | HPGDS (0.40) | HPGDSCYP3A4CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL9641996 | 0.83 | CNR1 (0.39) | SIGMAR1HPGDSCYP3A4CYP2D6CYP2A6 | |
| SCHEMBL27548657 | 0.80 | CYP2C9 (0.47) | HPGDSCYP3A4CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL6896976 | 0.80 | HPGDS (0.50) | HPGDSCYP3A4CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL10269258 | 0.80 | CYP19A1 (0.54) | HPGDSCYP3A4CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL6955809 | 0.79 | HPGDS (0.39) | SIGMAR1HPGDSCYP3A4CYP2D6CYP2A6 | |
| Hydrochloric Acid SCHEMBL7878223 | 0.78 | TDP1 (0.49) | HPGDSCYP3A4CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL30741761 | 0.77 | HPGDS (0.50) | SIGMAR1HPGDSCYP3A4CYP2D6CYP2A6 | |
| SCHEMBL28417084 | 0.77 | HPGDS (0.50) | HPGDSCYP3A4CYP2D6CYP2A6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |