Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 10/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111041 | 0.94 | CHRNA7 (0.48) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5114631 | 0.90 | CHRNB2 (0.51) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5122462 | 0.90 | CHRNB2 (0.48) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL5115272 | 0.89 | CHRNB2 (0.50) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5109547 | 0.85 | CHRNB2 (0.53) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5111574 | 0.81 | CHRNB2 (0.49) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL22171115 | 0.75 | CHRNA7 (0.51) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL6976933 | 0.74 | CHRNB4 (0.48) | CHRNA7CHRNB4CHRNA3HTR3A | |
| SCHEMBL5114505 | 0.73 | CHRNA7 (0.46) | CHRNA7MAPTHTR3A | |
| SCHEMBL5112611 | 0.73 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135389-B1 | 1,4-DIAZABICYCLO 3.2.2]NONANE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION | SANOFI SYNTHELABO (FR) | 2003-09-10 | — | — | EP | disclosed |
| US-6407095-B1 | TREATING NICOTINIC RECEPTOR, GASTROINTESTINAL, NERVOUS SYSTEM, PSYCHOLOGICAL, AND BRAIN DISORDERS | SANOFI-SYNTHELABO (FR) | 2002-06-18 | — | — | US | disclosed |