Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968129 | 0.89 | TP53 (0.53) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL17510088 | 0.87 | TP53 (0.51) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL21670253 | 0.79 | TSHR (0.62) | TSHRSMN1; SMN2ALDH1A1POLBMAPK1 | |
| SCHEMBL5022233 | 0.79 | TSHR (0.62) | TSHRSMN1; SMN2ALDH1A1POLBMAPK1 | |
| SCHEMBL3377958 | 0.78 | TP53 (0.61) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL295415 | 0.78 | TP53 (0.45) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3282634 | 0.77 | TP53 (0.55) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL25939640 | 0.77 | TP53 (0.55) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL25939514 | 0.77 | TP53 (0.55) | TP53TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL30150610 | 0.75 | LMNA (0.42) | SMN1; SMN2ALDH1A1POLBMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355648-A2 | 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a) | Bristol-Myers Squibb Pharma Company (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002055491-A2 | 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a) | BRISTOL MYERS SQUIBB COMPANY P (US) | 2002-07-18 | — | — | WO | disclosed |