Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSF1 | Q00613 | 2/20 | 0.60 |
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
| ▸ | PIR | O00625 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | SMO | Q99835 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972795 | 0.93 | BRAF (0.61) | HSF1BRAFPIRGSK3BCSF1R | |
| SCHEMBL6974172 | 0.92 | BRAF (0.60) | HSF1BRAFPIRGSK3BCSF1R | |
| SCHEMBL6487036 | 0.81 | MAPK14 (0.66) | HSF1BRAFPIRGSK3BMAPK14 | |
| SCHEMBL6971304 | 0.81 | BRAF (0.65) | HSF1BRAFCSF1RMAPK14SMO | |
| SCHEMBL6979731 | 0.80 | MAPK14 (0.69) | HSF1BRAFCSF1RMAPK14SMO | |
| SCHEMBL2976357 | 0.79 | HSF1 (0.63) | HSF1BRAFCSF1RMAPK14SMO | |
| SCHEMBL16621178 | 0.78 | HSF1 (0.90) | HSF1BRAFPIRGSK3BMAPK14 | |
| SCHEMBL716373 | 0.78 | ABL1 (0.63) | BRAFCSF1RMAPK14KDR | |
| SCHEMBL6979265 | 0.78 | BRAF (0.77) | HSF1BRAFCSF1RMAPK14SMO | |
| SCHEMBL5897251 | 0.78 | BRAF (0.76) | HSF1BRAFCSF1RMAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |