Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.69 |
| ▸ | SMO | Q99835 | 11/20 | 0.69 |
| ▸ | BRAF | P15056 | 2/20 | 0.64 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979946 | 0.93 | MAPK14 (0.74) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL6971304 | 0.90 | BRAF (0.65) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL7827201 | 0.89 | MAPK14 (0.65) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL6979265 | 0.84 | BRAF (0.77) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL5897251 | 0.84 | BRAF (0.76) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL6977566 | 0.83 | BRAF (0.62) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL6972795 | 0.82 | BRAF (0.61) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL6975716 | 0.81 | BRAF (0.72) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL6974172 | 0.81 | BRAF (0.60) | MAPK14SMOBRAFCSF1RHSF1 | |
| SCHEMBL5897487 | 0.80 | CSF1R (0.81) | MAPK14SMOBRAFCSF1RHSF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |