Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.61 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.61 |
| ▸ | PIR | O00625 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974172 | 0.99 | BRAF (0.60) | BRAFHSF1PIRGSK3BCSF1R | |
| SCHEMBL6969300 | 0.93 | HSF1 (0.60) | BRAFHSF1PIRGSK3BCSF1R | |
| SCHEMBL6971304 | 0.82 | BRAF (0.65) | BRAFHSF1CSF1RMAPK14NPC1 | |
| SCHEMBL6979731 | 0.82 | MAPK14 (0.69) | BRAFHSF1CSF1RMAPK14NPC1 | |
| SCHEMBL6487036 | 0.80 | MAPK14 (0.66) | BRAFHSF1PIRGSK3BKDR | |
| SCHEMBL6979265 | 0.80 | BRAF (0.77) | BRAFHSF1CSF1RMAPK14NPC1 | |
| SCHEMBL5897251 | 0.80 | BRAF (0.76) | BRAFHSF1CSF1RMAPK14NPC1 | |
| SCHEMBL5897487 | 0.77 | CSF1R (0.81) | BRAFHSF1CSF1RMAPK14NPC1 | |
| SCHEMBL5005096 | 0.77 | BRAF (0.52) | BRAFHSF1PIRGSK3BCSF1R | |
| SCHEMBL6975716 | 0.77 | BRAF (0.72) | BRAFHSF1PIRCSF1RMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |