Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955450 | 0.94 | DRD2 (0.53) | DRD2SLC6A4ADRA1DHTR2AHTR1A | |
| SCHEMBL6956398 | 0.92 | DRD2 (0.49) | DRD2SLC6A4ADRA1DHTR2AHTR1A | |
| SCHEMBL6957823 | 0.92 | DRD2 (0.49) | DRD2SLC6A4ADRA1DHTR2AHTR1A | |
| SCHEMBL6961404 | 0.91 | CYP2D6 (0.48) | DRD2SLC6A4ADRA1DHTR2AHTR1A | |
| SCHEMBL6956812 | 0.85 | DRD2 (0.48) | DRD2SLC6A4HTR1ADRD3OPRM1 | |
| SCHEMBL6968059 | 0.85 | DRD2 (0.48) | DRD2SLC6A4HTR1ADRD3OPRM1 | |
| SCHEMBL6968341 | 0.85 | OPRM1 (0.52) | DRD2SLC6A4HTR2AHTR1ADRD3 | |
| SCHEMBL6956151 | 0.85 | OPRM1 (0.52) | DRD2SLC6A4HTR2AHTR1ADRD3 | |
| SCHEMBL6957106 | 0.85 | DRD2 (0.48) | DRD2SLC6A4HTR1ADRD3OPRM1 | |
| SCHEMBL6965715 | 0.85 | OPRM1 (0.52) | DRD2SLC6A4HTR2AHTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |