Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498396 | 0.79 | ENPP2 (0.47) | ALDH1A1KDM4ENPSR1NR1H2DPP8 | |
| SCHEMBL6973736 | 0.74 | ALDH1A1 (0.56) | ALDH1A1LMNANPSR1NR1H2DPP4 | |
| SCHEMBL6972682 | 0.73 | NR1H2 (0.51) | KDM4ENR1H2DPP4DPP8DPP7 | |
| SCHEMBL4503991 | 0.73 | HDAC6 (0.59) | ALDH1A1KDM4ELMNAHSD17B10NR1H2 | |
| SCHEMBL6969736 | 0.72 | NR1H2 (0.47) | ALDH1A1KDM4ELMNATP53NPSR1 | |
| SCHEMBL6973945 | 0.72 | NR1H2 (0.52) | ALDH1A1KDM4ELMNANPSR1HSD17B10 | |
| SCHEMBL6973919 | 0.71 | NR1H2 (0.51) | ALDH1A1KDM4ELMNANPSR1HSD17B10 | |
| SCHEMBL6957857 | 0.71 | NR1H2 (0.57) | KDM4ENR1H2DPP4DPP8DPP7 | |
| SCHEMBL6960916 | 0.71 | NR1H2 (0.48) | KDM4EHSD17B10NR1H2DPP4DPP8 | |
| SCHEMBL6961357 | 0.71 | HPGD (0.49) | ALDH1A1KDM4ELMNANPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |