Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.36 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 4/20 | 0.35 |
| ▸ | CES2 | O00748 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405360 | 0.81 | FFAR1 (0.33) | HPGDALDH1A1HSD17B10CYP1A2CYP2C9 | |
| SCHEMBL274958 | 0.80 | TTR (0.49) | TTRLMNAF2HPGDMAPT | |
| SCHEMBL28938346 | 0.78 | FFAR1 (0.31) | FFAR1 | |
| SCHEMBL8359013 | 0.76 | NPC1 (0.48) | TTRLMNAHPGDMAPTALDH1A1 | |
| SCHEMBL26038959 | 0.76 | CES1 (0.48) | TTRLMNAF2HPGDMAPT | |
| SCHEMBL6972687 | 0.76 | CA12 (0.36) | HPGDALDH1A1CES1CES2CA12 | |
| SCHEMBL10226685 | 0.73 | ALDH1A1 (0.58) | TTRLMNAHPGDMAPTALDH1A1 | |
| SCHEMBL2571596 | 0.71 | LMNA (0.33) | LMNA | |
| SCHEMBL6219628 | 0.71 | ALDH1A1 (0.39) | ALDH1A1RAB9A | |
| SCHEMBL315777 | 0.71 | ALDH1A1 (0.61) | LMNAHPGDMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |