Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 8/20 | 0.54 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 3/20 | 0.40 |
| ▸ | BAD | Q92934 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970081 | 0.93 | TRAP1 (0.47) | TRAP1HSP90B1MGLLABHD6MEN1 | |
| SCHEMBL6969523 | 0.93 | TRAP1 (0.47) | TRAP1HSP90B1MGLLABHD6MEN1 | |
| SCHEMBL6968726 | 0.91 | TRAP1 (0.46) | TRAP1HSP90B1MEN1KMT2ABCL2 | |
| SCHEMBL3243617 | 0.89 | HSP90B1 (0.43) | TRAP1HSP90B1HSP90AA1HSP90AB1MEN1 | |
| SCHEMBL3246757 | 0.87 | NAMPT (0.40) | TRAP1HSP90B1MEN1KMT2ABCL2 | |
| SCHEMBL384058 | 0.85 | TRAP1 (0.58) | TRAP1HSP90B1MGLLABHD6HSP90AA1 | |
| SCHEMBL3772834 | 0.85 | THRB (0.43) | TRAP1HSP90B1MEN1KMT2ABCL2 | |
| SCHEMBL3244310 | 0.84 | TRAP1 (0.62) | TRAP1HSP90B1MGLLABHD6HSP90AA1 | |
| SCHEMBL382845 | 0.83 | TRAP1 (0.57) | TRAP1HSP90B1MGLLABHD6HSP90AA1 | |
| SCHEMBL3772822 | 0.80 | TRAP1 (0.64) | TRAP1HSP90B1MGLLABHD6HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181092-B1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| US-8183279-B2 | 1,3-dihydroisoindole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-22 | — | — | US | disclosed |
| US-8183279-B2 | 1,3-dihydroisoindole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-22 | — | — | US | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| WO-2009030316-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | HSP90AB1, HSP90AA1, HSP90AB2P | TRAP1 11/4885HSP90B1 4/4885MGLL 4697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.