Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964280 | 0.89 | PDE4B (0.54) | PDE4BCYP19A1PDE4DPDE4APDE4C | |
| SCHEMBL6656328 | 0.83 | PDE4B (0.68) | PDE4BCYP19A1PDE4DPDE4APDE4C | |
| SCHEMBL6961901 | 0.82 | PDE4B (0.48) | PDE4BCYP19A1PDE4DPDE4APDE4C | |
| SCHEMBL7082293 | 0.80 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6685828 | 0.80 | LMNA (0.51) | PDE4B | |
| SCHEMBL6662258 | 0.80 | FLT1 (0.45) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6662743 | 0.80 | TSHR (0.52) | PDE4B | |
| SCHEMBL6842307 | 0.80 | FLT1 (0.44) | PDE4B | |
| SCHEMBL6843934 | 0.79 | FLT1 (0.42) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6844104 | 0.79 | FLT1 (0.43) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |