Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.54 |
| ▸ | PDE4A | P27815 | 7/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964280 | 0.89 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6656546 | 0.83 | PDE4B (0.78) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6971014 | 0.82 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6955736 | 0.82 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6969501 | 0.80 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6657264 | 0.79 | TSHR (0.51) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6841795 | 0.79 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6683275 | 0.79 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6657725 | 0.78 | SMN1; SMN2 (0.52) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6653049 | 0.78 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |