Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 5/20 | 0.47 |
| ▸ | CES1 | P23141 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969551 | 1.00 | CYP11B1 (0.49) | CYP11B1CYP11B2TSHRRAB9AALDH1A1 | |
| SCHEMBL21051326 | 0.81 | MAOB (0.61) | CYP11B1CYP11B2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21051327 | 0.81 | MAOB (0.61) | CYP11B1CYP11B2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1081436 | 0.81 | ALDH1A1 (0.45) | TSHRRAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1081432 | 0.81 | ALDH1A1 (0.45) | TSHRRAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL9642050 | 0.80 | TSHR (0.56) | TSHRRAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3559979 | 0.79 | CES2 (0.52) | RAB9AALDH1A1KMT2ASMN1; SMN2CES2 | |
| SCHEMBL5216998 | 0.77 | CES2 (0.50) | RAB9AALDH1A1KMT2ASMN1; SMN2CES2 | |
| SCHEMBL14368161 | 0.77 | CES2 (0.54) | RAB9AALDH1A1KMT2ASMN1; SMN2CES2 | |
| SCHEMBL8798863 | 0.77 | CES2 (0.54) | RAB9AALDH1A1KMT2ASMN1; SMN2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
| EP-0862560-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997019065-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |