Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961223 | 0.84 | TSHR (0.41) | MAPTRAB9ACNR2ALDH1A1GAA | |
| SCHEMBL6960917 | 0.83 | L3MBTL1 (0.43) | RAB9AGRM5ALDH1A1GAAPDE10A | |
| SCHEMBL6972820 | 0.80 | MEN1 (0.41) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL6964819 | 0.79 | PTK2 (0.46) | MAPTRAB9AGRM5ALDH1A1 | |
| SCHEMBL6967680 | 0.79 | KMT2A (0.38) | MAPTALDH1A1LMNANPSR1KMT2A | |
| SCHEMBL3873900 | 0.79 | SIRT1 (0.40) | HHATTSHRKMT2AMEN1 | |
| SCHEMBL6968127 | 0.78 | MAPK1 (0.39) | ALDH1A1LMNAGAATSHRNPSR1 | |
| SCHEMBL6967876 | 0.77 | MAPT (0.46) | MAPTRAB9AALDH1A1LMNAGAA | |
| SCHEMBL6961500 | 0.77 | TSHR (0.52) | ALDH1A1LMNAGAATSHRNPSR1 | |
| SCHEMBL6962527 | 0.76 | ACE (0.40) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |