Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888381 | 0.84 | LMNA (0.44) | ALDH1A1LMNAMAPK1KDM4EMAPT | |
| SCHEMBL5405617 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPK1DAOKDM4E | |
| SCHEMBL6970016 | 0.75 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL3816299 | 0.74 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPK1DAOKDM4E | |
| SCHEMBL1529532 | 0.72 | DAO (0.63) | ALDH1A1DAOKDM4EMAPTMEN1 | |
| SCHEMBL14507360 | 0.72 | DAO (0.57) | ALDH1A1LMNAMAPK1DAOKDM4E | |
| SCHEMBL21962947 | 0.71 | PTGS1 (0.45) | ALDH1A1LMNAMAPK1KDM4EMAPT | |
| SCHEMBL899479 | 0.71 | GSK3B (0.61) | ALDH1A1LMNADAOKDM4EMAPT | |
| Bromide SCHEMBL8935164 | 0.70 | GSK3B (0.59) | ALDH1A1LMNADAOKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL8935203 | 0.70 | GSK3B (0.59) | ALDH1A1LMNADAOKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676395-B1 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| CN-1073988-C | Substituted heteroaromatic acylguanidines, process for their preparation, their use as medicaments and medicaments containing them | HOECHST AG (DE) | 2001-10-31 | — | — | CN | disclosed |
| US-5698581-A | ANTIISCHEMIC AGENTS, ANTIARRHYTHMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-16 | — | — | US | disclosed |
| CN-1117044-A | Substituted heteroaromatic acylguanidines, process for their preparation, their use as medicaments and medicaments containing them | HOECHST AG (DE) | 1996-02-21 | — | — | CN | disclosed |
| EP-0676395-A2 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-11 | — | — | EP | disclosed |