SCHEMBL6970125

SCHEMBL6970125

BrCC/C=C1/c2ccccc2CSc2ccccc21

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.71
SLC6A2 P23975 6/20 0.68
HRH1 P35367 6/20 0.68
HTR2B P41595 5/20 0.68
KCNH2 Q12809 5/20 0.68
CHRM2 P08172 4/20 0.68
ADRA2A P08913 4/20 0.68
CYP2D6 P10635 4/20 0.68
CHRM1 P11229 4/20 0.68
DRD2 P14416 4/20 0.68
ADRA2B P18089 4/20 0.68
ADRA2C P18825 4/20 0.68
CHRM3 P20309 4/20 0.68
HTR2A P28223 4/20 0.68
HTR2C P28335 4/20 0.68
SLC6A4 P31645 4/20 0.68
ADRA1A P35348 4/20 0.68
DRD3 P35462 4/20 0.68
OPRK1 P41145 4/20 0.68
MC3R P41968 3/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL655611 1.00 ALDH1A1 (0.71) ALDH1A1SLC6A2HRH1HTR2BKCNH2
SCHEMBL655612 1.00 ALDH1A1 (0.71) ALDH1A1SLC6A2HRH1HTR2BKCNH2
SCHEMBL6967536 0.88 SLC6A2 (0.63) ALDH1A1SLC6A2HRH1HTR2BKCNH2
SCHEMBL6967533 0.88 SLC6A2 (0.63) ALDH1A1SLC6A2HRH1HTR2BKCNH2
SCHEMBL14288478 0.82 SLC6A2 (0.69) ALDH1A1SLC6A2HRH1HTR2BKCNH2
SCHEMBL11871057 0.81 SLC6A2 (0.68) ALDH1A1SLC6A2HRH1HTR2BKCNH2
SCHEMBL14386490 0.81 LMNA (0.97) ALDH1A1SLC6A2HRH1HTR2BKCNH2
Dothiepin SCHEMBL34483 0.81 HRH1 (1.00) ALDH1A1SLC6A2HRH1HTR2BKCNH2
Dothiepin SCHEMBL684145 0.81 HRH1 (1.00) ALDH1A1SLC6A2HRH1HTR2BKCNH2
Dothiepin SCHEMBL3374653 0.81 HRH1 (1.00) ALDH1A1SLC6A2HRH1HTR2BKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934313-B1 N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS NOVO NORDISK AS (DK) 2003-05-14 EP disclosed
EP-0934312-B1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK AS (DK) 2003-03-19 EP disclosed
EP-0869954-B1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF NEUROGENIC INFLAMMATION NOVO NORDISK AS (DK) 2001-09-19 EP disclosed
US-6133268-A 1,4-disubstituted piperazines NOVO NORDISK A/S (DK) 2000-10-17 US disclosed
US-6040302-A ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY NOVO NORDISK A/S (DK) 2000-03-21 US disclosed
US-6004983-A ANALGESICS; ANTIINFLAMMATORY, ANTIARTHRITIC AND ANTIDIABETIC AGENTS NOVO NORDISK A/S (DE) 1999-12-21 US disclosed
US-6004961-A ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES NOVO NORDISK A/S (DK) 1999-12-21 US disclosed
EP-0934312-A1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK A/S (DK) 1999-08-11 EP disclosed
WO-1998015548-A1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK A/S (DK) 1998-04-16 WO disclosed