Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.54 |
| ▸ | MTTP | P55157 | 12/20 | 0.52 |
| ▸ | APOB | P04114 | 11/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974830 | 0.89 | MTTP (0.56) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL6971759 | 0.86 | SMO (0.56) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL6974648 | 0.83 | MTTP (0.60) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL6966949 | 0.82 | MTTP (0.53) | SMOMTTPAPOB | |
| SCHEMBL6973182 | 0.81 | MTTP (0.52) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL6799386 | 0.81 | SMO (0.55) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL8201197 | 0.79 | SMO (0.63) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL6966884 | 0.78 | APOB (0.61) | SMOMTTPAPOBGAAKDM4E | |
| SCHEMBL8591888 | 0.78 | SMO (0.46) | SMOMTTPAPOBCHRNB2CHRNB4 | |
| SCHEMBL8208665 | 0.78 | MTTP (0.57) | SMOMTTPAPOBGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |