Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970152 | 1.00 | METAP1 (0.55) | METAP1MYCIL1RNERAP1MAPT | |
| SCHEMBL8172720 | 0.84 | MYC (0.54) | METAP1MYCIL1RNERAP1MAPT | |
| SCHEMBL8172716 | 0.84 | MYC (0.54) | METAP1MYCIL1RNERAP1MAPT | |
| SCHEMBL5525263 | 0.81 | MEN1 (0.65) | MAPTPIM1PTGS1PTGS2NPC1 | |
| SCHEMBL5525267 | 0.81 | MEN1 (0.65) | MAPTPIM1PTGS1PTGS2NPC1 | |
| SCHEMBL8172890 | 0.79 | MEN1 (0.58) | METAP1MAPTPIM1PTGS1PTGS2 | |
| SCHEMBL8172892 | 0.79 | MEN1 (0.58) | METAP1MAPTPIM1PTGS1PTGS2 | |
| SCHEMBL8180300 | 0.79 | MEN1 (0.54) | MAPTPIM1PTGS1PTGS2NPC1 | |
| SCHEMBL8180304 | 0.79 | MEN1 (0.54) | MAPTPIM1PTGS1PTGS2NPC1 | |
| SCHEMBL8187103 | 0.76 | KMT2A (0.55) | MAPTPTGS1PTGS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848004-B1 | PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-5955616-A | PROSTAGLANDIN INHIBITORS | SHIONOGI & CO., LTD. (JP) | 1999-09-21 | — | — | US | disclosed |
| EP-0848004-A1 | PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 1998-06-17 | — | — | EP | disclosed |