Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | NAT1 | P18440 | 1/20 | 0.48 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180300 | 1.00 | MEN1 (0.54) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL5525267 | 0.90 | MEN1 (0.65) | MEN1KMT2ANAT1PIP4K2APTGS1 | |
| SCHEMBL5525263 | 0.90 | MEN1 (0.65) | MEN1KMT2ANAT1PIP4K2APTGS1 | |
| SCHEMBL8172892 | 0.87 | MEN1 (0.58) | MEN1KMT2ANAT1PIP4K2APTGS1 | |
| SCHEMBL8172890 | 0.87 | MEN1 (0.58) | MEN1KMT2ANAT1PIP4K2APTGS1 | |
| SCHEMBL8180272 | 0.84 | SIRT2 (0.56) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL8180274 | 0.84 | SIRT2 (0.56) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL8181369 | 0.81 | METAP1 (0.49) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL6970152 | 0.79 | METAP1 (0.55) | MEN1KMT2APTGS1PTGS2HPGD | |
| SCHEMBL6970148 | 0.79 | METAP1 (0.55) | MEN1KMT2APTGS1PTGS2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018745-A1 | OXAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |