Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.66 |
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.66 |
| ▸ | IKBKB | O14920 | 3/20 | 0.62 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.59 |
| ▸ | PRKCG | P05129 | 3/20 | 0.59 |
| ▸ | PRKCB | P05771 | 3/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.59 |
| ▸ | PRKCA | P17252 | 3/20 | 0.59 |
| ▸ | PRKCH | P24723 | 3/20 | 0.59 |
| ▸ | PRKCI | P41743 | 3/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977338 | 0.95 | CDK2 (0.65) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6971022 | 0.88 | CDK2 (0.70) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6969186 | 0.86 | CDK2 (0.67) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| Dimethylamine SCHEMBL6977342 | 0.86 | CDK2 (0.67) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4732945 | 0.85 | PIK3CA (0.80) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| Dimethylamine SCHEMBL6970249 | 0.84 | CDK2 (0.70) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6980595 | 0.81 | CDK2 (0.66) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6978350 | 0.81 | ZAP70 (0.61) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6979315 | 0.81 | CDK2 (0.79) | CDK2EGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7476936 | 0.80 | IKBKB (0.72) | PIK3CAPIK3CBPIK3CGJAK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |