Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.72 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCND2 | P30279 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471337 | 0.94 | IKBKB (0.64) | IKBKBABL1BCRPIK3CAPIK3CB | |
| SCHEMBL7467622 | 0.88 | JAK2 (0.59) | IKBKBABL1BCRPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL8547700 | 0.87 | JAK2 (0.58) | IKBKBABL1BCRPIK3CAPIK3CB | |
| SCHEMBL7472256 | 0.87 | IKBKB (0.68) | IKBKBABL1BCRCDK4CCND1 | |
| SCHEMBL7470899 | 0.82 | ABL1 (0.67) | IKBKBABL1BCRJAK2HDAC6 | |
| SCHEMBL7465398 | 0.81 | PIK3CG (0.76) | IKBKBPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL12275887 | 0.81 | IKBKB (0.60) | IKBKBABL1BCRPIK3CAPIK3CB | |
| SCHEMBL11880071 | 0.80 | CYP1A2 (0.55) | IKBKBCDK4CCND1CCND2CCND3 | |
| SCHEMBL6970247 | 0.80 | CDK2 (0.66) | IKBKBABL1BCRPIK3CAPIK3CB | |
| SCHEMBL1887643 | 0.80 | MAPT (0.60) | IKBKBMEN1KMT2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |