Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961381 | 0.89 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRHSD17B10HCRTR2 | |
| SCHEMBL6962531 | 0.78 | NR1H2 (0.54) | HDAC8NR1H2ACEDPP8DPP7 | |
| SCHEMBL6974445 | 0.77 | NR1H2 (0.51) | ALDH1A1KDM4ETSHRHSD17B10HDAC8 | |
| SCHEMBL381428 | 0.77 | NR1H2 (0.56) | HDAC8NR1H2HSD17B3KMT2ATMPRSS2 | |
| SCHEMBL6972828 | 0.77 | HPGD (0.56) | ALDH1A1NR1H2KMT2ATMPRSS2 | |
| SCHEMBL6974571 | 0.76 | NR1H2 (0.52) | HDAC8NR1H2ACEDPP8DPP7 | |
| SCHEMBL6961304 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KDM4ETSHRHSD17B10KMT2A | |
| SCHEMBL27041869 | 0.73 | TMEM97 (0.67) | NR1H2 | |
| SCHEMBL6965291 | 0.73 | NPC1 (0.57) | ALDH1A1KDM4ETSHRHSD17B10NR1H2 | |
| SCHEMBL3858227 | 0.73 | NOTUM (0.63) | HDAC8NR1H2HSD17B3KMT2ATMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |