Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969528 | 0.94 | PGK1 (0.50) | PGK1ALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL1048487 | 0.80 | KDM4E (0.58) | LMNASMN1; SMN2TSHRKDM4ERAD52 | |
| SCHEMBL7261471 | 0.74 | CYP1A2 (0.56) | ALDH1A1LMNASMN1; SMN2KDM4ERAD52 | |
| SCHEMBL11795058 | 0.73 | PGK1 (0.48) | PGK1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL24463170 | 0.72 | KDM4E (0.53) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E | |
| SCHEMBL30389867 | 0.72 | KDM4E (0.53) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E | |
| SCHEMBL8775998 | 0.70 | PGK1 (0.45) | PGK1ALDH1A1LMNATSHRKDM4E | |
| SCHEMBL11555842 | 0.70 | KDM4E (0.51) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E | |
| SCHEMBL16806057 | 0.70 | CYP1A2 (0.60) | LMNASMN1; SMN2TSHRKDM4ERAD52 | |
| SCHEMBL11531138 | 0.70 | KDM4E (0.50) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |