Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976524 | 0.78 | DHFR (0.46) | ALDH1A1TSHRLMNAGPR84DRD2 | |
| SCHEMBL6961921 | 0.76 | POLB (0.55) | ALDH1A1TSHRLMNAPOLBABCB1 | |
| SCHEMBL6974145 | 0.76 | ALDH1A1 (0.43) | ALDH1A1TSHRLMNADRD2DRD4 | |
| SCHEMBL6969248 | 0.75 | BCHE (0.57) | TSHRLMNAHTR2ADRD2DRD4 | |
| SCHEMBL6975713 | 0.75 | ALDH1A1 (0.56) | ALDH1A1TSHRLMNADRD2DRD4 | |
| SCHEMBL6964021 | 0.75 | PDE4B (0.52) | ALDH1A1TSHRDRD4POLBABCB1 | |
| SCHEMBL6392089 | 0.75 | HTT (0.51) | ALDH1A1TSHRLMNAHTR2ASMN1; SMN2 | |
| SCHEMBL6973388 | 0.74 | TMEM97 (0.60) | DRD2DRD4DRD3DHFRMEN1 | |
| SCHEMBL6960871 | 0.74 | ALDH1A1 (0.40) | ALDH1A1TSHRDRD2DRD4DRD3 | |
| SCHEMBL6974504 | 0.73 | TP53 (0.57) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |