Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656098 | 0.83 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6964280 | 0.83 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7082293 | 0.82 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6973161 | 0.82 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6962406 | 0.81 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6658910 | 0.80 | SMN1; SMN2 (0.46) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6686004 | 0.80 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6654761 | 0.80 | NPSR1 (0.51) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6661702 | 0.79 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6658092 | 0.79 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |