Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 7/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971981 | 0.96 | TRAP1 (0.43) | TRAP1HSP90B1HRH3HSP90AA1 | |
| SCHEMBL6970347 | 0.93 | TRAP1 (0.45) | TRAP1HSP90B1HRH3XDHHSP90AA1 | |
| SCHEMBL6971008 | 0.93 | HRH3 (0.47) | TRAP1HSP90B1HRH3MAOB | |
| SCHEMBL6971423 | 0.93 | TRAP1 (0.41) | TRAP1HSP90B1HRH3HSP90AA1MAOB | |
| SCHEMBL6971062 | 0.93 | HRH3 (0.49) | TRAP1HSP90B1HRH3MAOB | |
| SCHEMBL6971386 | 0.89 | TRAP1 (0.44) | TRAP1HSP90B1HRH3HSP90AA1MAOB | |
| SCHEMBL6971836 | 0.89 | TRAP1 (0.44) | TRAP1HSP90B1HRH3MAOB | |
| SCHEMBL6971311 | 0.89 | TRAP1 (0.41) | TRAP1HSP90B1HSP90AA1 | |
| SCHEMBL6968228 | 0.89 | MGLL (0.45) | TRAP1HSP90B1HRH3HSP90AA1MAOB | |
| SCHEMBL6972476 | 0.87 | TRAP1 (0.58) | TRAP1HSP90B1HRH3HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183279-B2 | 1,3-dihydroisoindole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-22 | — | — | US | disclosed |
| US-8183279-B2 | 1,3-dihydroisoindole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-22 | — | — | US | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | HSP90AB1, HSP90AA1, HSP90AB2P | TRAP1 11/4885HSP90B1 4/4885HRH3 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.