Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | MDM4 | O15151 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | F11 | P03951 | 2/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.56 |
| ▸ | CFD | P00746 | 2/20 | 0.56 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL7517546 | 0.97 | HDAC3 (0.57) | HDAC3HDAC1HDAC2MAPK1KCNK3 | |
| SCHEMBL23230036 | 0.88 | GAA (0.55) | HDAC3HDAC1HDAC2MAPK1KCNK3 | |
| SCHEMBL28767764 | 0.87 | SUCNR1 (0.58) | HDAC3HDAC1HDAC2MAPK1KCNK3 | |
| SCHEMBL28242708 | 0.86 | SUCNR1 (0.71) | HDAC3HDAC1HDAC2KCNK3KCNK9 | |
| SCHEMBL528445 | 0.84 | KCNK3 (0.77) | HDAC3HDAC1HDAC2MAPK1KCNK3 | |
| SCHEMBL3635005 | 0.83 | ALDH1A1 (0.47) | HDAC3HDAC1HDAC2KCNK3KCNK9 | |
| SCHEMBL28201120 | 0.83 | KMT2A (0.72) | HDAC2KCNK3KCNK9TP53POLB | |
| SCHEMBL27758988 | 0.83 | GAA (0.58) | HDAC3HDAC1HDAC2MAPK1NPC1 | |
| SCHEMBL27841708 | 0.83 | MAPT (0.48) | HDAC3HDAC1HDAC2MAPK1KCNK3 | |
| SCHEMBL28746605 | 0.82 | KCNK3 (0.56) | KCNK3KCNK9TP53POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473429-A | ROR gamma modulators | 领先制药控股公司 | 2018-08-31 | — | — | CN | claimed |
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | claimed |
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | LEAD DISCOVERY CENTER GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| WO-2019197549-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | QURIENT CO., LTD. (KR) | 2019-10-17 | — | — | WO | disclosed |
| CN-110218158-A | A method of photocatalytic synthesis is at amide compound in water phase | 福建医科大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-110023302-A | 2,4, 5-trisubstituted 1,2, 4-triazolones as DHODH inhibitors | 拜耳股份有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-107628964-B | A kind of synthetic method of N- aryl Zhong Fang amide | 陕西科技大学 | 2019-06-21 | — | — | CN | disclosed |
| EP-3008045-B1 | ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS | ANTABIO SAS (FR) | 2018-05-09 | — | — | EP | disclosed |
| CN-107628964-A | A kind of synthetic method of N aryl Zhong Fang acid amides | 陕西科技大学 | 2018-01-26 | — | — | CN | disclosed |
| CN-105669491-B | A kind of acylation method of amine | 苏州大学 | 2017-10-13 | — | — | CN | disclosed |
| CN-105669491-A | Acidylation method of amine | 苏州大学 | 2016-06-15 | — | — | CN | disclosed |
| CN-100548948-C | Metal ligands and improved metal catalytic processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2009-10-14 | — | — | CN | disclosed |
| CN-100334067-C | Purification method for amide and sulfonylamine compound synthesized from liquid phase | UNIV ZHEJIANG (CN) | 2007-08-29 | — | — | CN | disclosed |
| CN-1762984-A | Purification method for amide and sulfonylamine compound synthesized from liquid phase | UNIV ZHEJIANG (CN) | 2006-04-26 | — | — | CN | disclosed |
| US-20020032262-A1 | 2-aminoarylmethylamine solid support templated for preparation of highly functionalized heterocycle compounds | ZHANG JINFANG (US) | 2002-03-14 | — | — | US | disclosed |
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | CDK1, CDK2, CDK15 | HDAC3 1189/4885HDAC1 533/4885HDAC2 813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.