Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971265 | 1.00 | JAK3 (0.41) | JAK3ALDH1A1SMN1; SMN2KITPDGFRA | |
| SCHEMBL8189893 | 0.93 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL8189897 | 0.93 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL16684971 | 0.93 | PTGES (0.39) | JAK3ALDH1A1SMN1; SMN2KITPDGFRA | |
| SCHEMBL29351460 | 0.93 | PTGES (0.39) | JAK3ALDH1A1SMN1; SMN2KITPDGFRA | |
| SCHEMBL12700719 | 0.93 | PTGES (0.39) | JAK3ALDH1A1SMN1; SMN2KITPDGFRA | |
| SCHEMBL16684970 | 0.93 | PTGES (0.39) | JAK3ALDH1A1SMN1; SMN2KITPDGFRA | |
| SCHEMBL8191861 | 0.92 | KIT (0.39) | ALDH1A1SMN1; SMN2KITPDGFRAKDR | |
| SCHEMBL6982734 | 0.92 | PPARG (0.39) | ALDH1A1SMN1; SMN2KITPDGFRAKDR | |
| SCHEMBL8191858 | 0.92 | KIT (0.39) | ALDH1A1SMN1; SMN2KITPDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |