SCHEMBL6971348

SCHEMBL6971348

CCn1c(CCC(=O)O)nc(C(C)C)c1Sc1cccc([N+](=O)[O-])c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.38
CYP2C19 P33261 3/20 0.38
CYP1A2 P05177 2/20 0.38
FFAR1 O14842 1/20 0.38
CFTR P13569 1/20 0.37
IRAK4 Q9NWZ3 2/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37
GAA P10253 1/20 0.37
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSP90AA1 P07900 1/20 0.36
POLB P06746 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KDR P35968 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6971341 1.00 CYP2C9 (0.38) CYP2C9CYP2C19CYP1A2FFAR1CFTR
SCHEMBL7080984 0.89 LMNA (0.38) CYP2C9CYP2C19CYP1A2CFTRIRAK4
SCHEMBL8345499 0.89 FFAR1 (0.39) CYP2C9CYP2C19FFAR1IRAK4MAPT
SCHEMBL8345494 0.89 FFAR1 (0.39) CYP2C9CYP2C19FFAR1IRAK4MAPT
SCHEMBL6965158 0.88 PDE4A (0.37) FFAR1MAPTLMNAALDH1A1HPGD
SCHEMBL6965153 0.88 PDE4A (0.37) FFAR1MAPTLMNAALDH1A1HPGD
SCHEMBL7082403 0.88 HSP90AA1 (0.36) CYP2C9CYP2C19CYP1A2CFTRIRAK4
SCHEMBL6972424 0.87 LMNA (0.40) CYP2C9CYP2C19CYP1A2CFTRIRAK4
SCHEMBL6961422 0.87 HSP90AA1 (0.39) CYP2C9CYP2C19CYP1A2CFTRIRAK4
SCHEMBL6964051 0.86 IRAK4 (0.35) CYP2C9CYP2C19CYP1A2CFTRIRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed