Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | PRKCA | P17252 | 1/20 | 0.58 |
| ▸ | PRKCH | P24723 | 1/20 | 0.58 |
| ▸ | PRKCI | P41743 | 1/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981443 | 0.89 | MEN1 (0.58) | MEN1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL6981393 | 0.87 | MEN1 (0.59) | MEN1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL6034114 | 0.86 | KDR (0.70) | MEN1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL6973424 | 0.84 | PTK2 (0.61) | MEN1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL6967890 | 0.80 | MAPT (0.56) | MEN1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL6974310 | 0.79 | ZAP70 (0.80) | CDK2PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6319664 | 0.77 | IGF1R (0.53) | MEN1CYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL7241620 | 0.77 | KDR (0.70) | CDK2PLK1PTK2JAK2KDR | |
| SCHEMBL8035912 | 0.77 | KDR (0.70) | PLK1PTK2JAK2INSRKDR | |
| SCHEMBL17544503 | 0.76 | PTK2 (0.76) | CDK2PTK2ALKKDRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |