Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 6/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.60 |
| ▸ | PLK1 | P53350 | 3/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.60 |
| ▸ | PRKCG | P05129 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | FLT4 | P35916 | 2/20 | 0.60 |
| ▸ | CDC7 | O00311 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971554 | 0.84 | MEN1 (0.62) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL6981443 | 0.81 | MEN1 (0.58) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL6981393 | 0.79 | MEN1 (0.59) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL4031710 | 0.78 | PTK2 (0.85) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL6034114 | 0.78 | KDR (0.70) | PTK2KDRPLK1IGF1RPRKD3 | |
| Hydrochloric Acid SCHEMBL3814733 | 0.78 | PTK2 (0.83) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL4024606 | 0.76 | PTK2 (0.85) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL1040134 | 0.76 | PTK2 (0.70) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL13866468 | 0.76 | PTK2 (0.85) | PTK2KDRPLK1IGF1RPRKD3 | |
| SCHEMBL12529085 | 0.76 | PTK2 (1.00) | PTK2KDRIGF1RLCKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |