Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641386 | 0.80 | SMN1; SMN2 (0.38) | TSHRCTSKALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL8769819 | 0.80 | TSHR (0.37) | TSHRCTSKALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL27749673 | 0.80 | CTSK (0.54) | TSHRCTSK | |
| SCHEMBL18776567 | 0.78 | TSHR (0.43) | TSHRCTSKALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL12283742 | 0.77 | TSHR (0.39) | TSHRALOX15SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL10828218 | 0.77 | TSHR (0.39) | TSHRALOX15SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL29321152 | 0.77 | TSHR (0.34) | TSHRCTSKALOX15SMN1; SMN2CYP1A2 | |
| SCHEMBL606444 | 0.76 | — | — | |
| SCHEMBL606445 | 0.76 | — | — | |
| SCHEMBL969919 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |