Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975067 | 0.89 | IP6K1 (0.35) | CHRNB2CHRNA4SYKIP6K1CHEK2 | |
| SCHEMBL3275913 | 0.82 | SRC (0.49) | PIK3CDPIK3CAPIK3CBSYKSRC | |
| SCHEMBL6978768 | 0.82 | SRC (0.44) | CHRNB2CHRNA4SRCKDRMKNK1 | |
| SCHEMBL16747710 | 0.81 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBSYKSRC | |
| SCHEMBL16742355 | 0.76 | HRH3 (0.42) | SRC | |
| SCHEMBL3364695 | 0.72 | CHEK2 (0.46) | IP6K1CHEK2 | |
| SCHEMBL3276361 | 0.71 | DRD2 (0.43) | SYKSRCKDRIP6K1 | |
| SCHEMBL7259617 | 0.71 | SRC (0.36) | CHRNB2CHRNA4SRCKDRMKNK1 | |
| SCHEMBL5678947 | 0.71 | EGFR (0.36) | SRCKDR | |
| SCHEMBL3275663 | 0.71 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBSYKIP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |