Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.44 |
| ▸ | KDR | P35968 | 12/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CSK | P41240 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259617 | 0.89 | SRC (0.36) | SRCKDRCHRNB2CHRNA4MKNK1 | |
| SCHEMBL6971728 | 0.82 | CHRNB2 (0.42) | SRCKDRCHRNB2CHRNA4MKNK1 | |
| SCHEMBL6970862 | 0.81 | SRC (0.47) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3277012 | 0.81 | SRC (0.61) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6966011 | 0.77 | SRC (0.41) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3367547 | 0.71 | CHEK2 (0.44) | AURKB | |
| Hydrochloric Acid SCHEMBL5734915 | 0.71 | SRC (0.56) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6975067 | 0.71 | IP6K1 (0.35) | CHRNB2CHRNA4AURKB | |
| SCHEMBL3275694 | 0.70 | SRC (0.49) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6463012 | 0.69 | SRC (0.39) | SRCKDRCHRNB2CHRNA4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |