Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 17/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964288 | 0.86 | DHPS (0.61) | DHPSALDH1A1AR | |
| SCHEMBL28589605 | 0.85 | DHPS (0.82) | DHPS | |
| SCHEMBL7303389 | 0.84 | DHPS (0.81) | DHPSALDH1A1 | |
| SCHEMBL28584053 | 0.83 | DHPS (0.82) | DHPS | |
| SCHEMBL7293762 | 0.83 | DHPS (0.82) | DHPSALDH1A1HPGD | |
| SCHEMBL28581580 | 0.83 | DHPS (0.82) | DHPS | |
| SCHEMBL28916573 | 0.82 | DHPS (0.83) | DHPS | |
| SCHEMBL4071996 | 0.81 | DHPS (0.67) | DHPS | |
| SCHEMBL5035040 | 0.79 | DHPS (0.53) | DHPSALDH1A1HPGD | |
| SCHEMBL5039384 | 0.77 | DHPS (0.62) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |