Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226660 | 0.78 | POLB (0.62) | POLBPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL7226664 | 0.78 | POLB (0.62) | POLBPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL3719656 | 0.77 | POLB (0.61) | POLBALDH1A1RAB9ATDP1 | |
| SCHEMBL5723219 | 0.77 | MME (0.47) | POLBPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL1381814 | 0.76 | POLB (0.53) | POLBPKMALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL12995467 | 0.76 | POLB (0.53) | POLBPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL2881064 | 0.76 | ALDH1A1 (0.62) | POLBALDH1A1RAB9ATDP1 | |
| SCHEMBL6978545 | 0.75 | CA9 (0.56) | ALDH1A1 | |
| SCHEMBL6978548 | 0.75 | CA9 (0.56) | ALDH1A1 | |
| SCHEMBL7141834 | 0.75 | LMNA (0.42) | POLBPKMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317428-A1 | PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002006224-A1 | PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |