Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 17/20 | 0.54 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.49 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701281 | 0.97 | AVPR2 (0.56) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6970484 | 0.94 | AVPR2 (0.55) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6966950 | 0.92 | AVPR2 (0.52) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6970694 | 0.92 | AVPR2 (0.52) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6967669 | 0.90 | AVPR2 (0.56) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6959290 | 0.90 | AVPR2 (0.52) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6965665 | 0.90 | AVPR2 (0.53) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6972761 | 0.89 | AVPR2 (0.52) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6971132 | 0.89 | AVPR2 (0.54) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6958364 | 0.89 | AVPR2 (0.52) | AVPR2AVPR1AOXTRAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620216-B1 | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5521170-A | VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| EP-0620216-A1 | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |