Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 13/20 | 0.42 |
| ▸ | EDNRA | P25101 | 4/20 | 0.40 |
| ▸ | EDNRB | P24530 | 3/20 | 0.40 |
| ▸ | SGK1 | O00141 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961036 | 0.91 | DHPS (0.51) | DHPSEDNRAEDNRBSGK1 | |
| SCHEMBL5654640 | 0.88 | EDNRA (0.51) | DHPSEDNRAEDNRB | |
| SCHEMBL25234371 | 0.87 | EDNRA (0.50) | DHPSEDNRAEDNRB | |
| SCHEMBL5631564 | 0.82 | EDNRB (0.43) | DHPSEDNRAEDNRB | |
| SCHEMBL6972701 | 0.81 | EDNRA (0.60) | DHPSEDNRAEDNRB | |
| SCHEMBL6974941 | 0.80 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL6973000 | 0.79 | EDNRA (0.43) | DHPSEDNRAEDNRB | |
| SCHEMBL5632829 | 0.79 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL5632224 | 0.79 | EDNRB (0.42) | DHPSEDNRAEDNRB | |
| SCHEMBL6965313 | 0.79 | EDNRA (0.49) | DHPSEDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | claimed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | claimed |
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |